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	Provedor de dados BABT (1) Autor Ding,Lei (1) Wang,Houlei (1) Wu,Jingping (1) Zeng,Qingmin (1) Zhang,Xinchao (1) Palavra-chave ANA (1) Heregulin-1β (1) MiR-21 (1) Peripheral nerve injury (1) SKP-SC (1) SOX2 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2016 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Heregulin-1β Promotes the Synergistic Effect Between Allogenic Skin-Derived Precursor Differentiated Schwann Cells (SKP-SC) and Acellular Nerve Allograft (ANA) in Peripheral Nerve Regeneration Through Inhibiting Mir-21 BABT Wang,Houlei; Wu,Jingping; Zhang,Xinchao; Ding,Lei; Zeng,Qingmin. Previous studies in our lab found that heregulin-1β with SKP-SCs (neurons and Schwann cells differentiated from SKPs) / ANA (acellular nerve allograft) transplantation represented a powerful therapeutic approach, and facilitates the efficacy of ANA in peripheral nerve injury. In this study, our purpose is to explore the mechanism between them. Firstly we transplanted ANA + SKP-SC + heregulin-1β into rats with right sciatic nerve injury and then detected the miR-21 and SOX2 (SRY-like HMG box 2) levels. Then we transfected miR-21 inhibitor in SCs (Schwann cells) which induced in hypoxic condition before harvesting. Then we detected expression of miR-21 and SOX2 using real time-PCR and western blot assay. Results in vivo showed that the expression of miR-21... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peripheral nerve injury; ANA; SKP-SC; Heregulin-1β; MiR-21; SOX2. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100321 Registros recuperados: 1 Primeira ... 1 ... Última

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